Understanding how malaria parasites develop in humans and mosquitoes
Plasmodium falciparum gametocytogenesis in vitro and in vivo
This study is looking at how certain factors affect the amount of malaria parasites in their sexual stage, called gametocytes, in people who are infected, so we can find out who might be more likely to spread malaria and help create better treatments to stop it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10754549 on NIH RePORTER |
What this research studies
This research investigates the production of sexual stage malaria parasites, known as gametocytes, which are essential for malaria transmission from humans to mosquitoes. The study aims to identify factors that influence the levels of these gametocytes in the blood of infected individuals, as higher levels increase the likelihood of spreading malaria. By developing a new assay to quantify these gametocytes, researchers hope to better understand the variations in gametocyte production among patients and identify those who may be at higher risk of transmitting the disease. This could lead to targeted treatments that prevent the spread of malaria.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young individuals aged 0-21 years who are infected with malaria, particularly in regions where malaria is endemic.
Not a fit: Patients who are not infected with malaria or those outside the targeted age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for malaria prevention and control, ultimately reducing transmission rates.
How similar studies have performed: Previous research has shown success in understanding malaria transmission dynamics, but this specific approach to quantifying gametocyte levels is relatively novel.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Williamson, Kim C — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Williamson, Kim C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.