Understanding how malaria parasites change their surface proteins to evade the immune system
A structured transcriptional switching network that coordinates antigenic variation by malaria parasites
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10684248
This study looks at how the malaria parasite changes its surface proteins to hide from the immune system, especially in young children in Africa, to help find better ways to prevent and treat severe malaria symptoms like anemia and cerebral malaria.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10684248 on ClinicalTrials.gov |
What this research studies
This research investigates how the malaria parasite Plasmodium falciparum alters its surface proteins to escape detection by the immune system, particularly in young children in Africa. By examining the mechanisms of antigenic variation, the study aims to understand how these changes contribute to severe malaria symptoms, such as anemia and cerebral malaria. The research employs advanced genetic and molecular techniques to analyze the expression of specific genes responsible for these surface protein changes. This knowledge could lead to improved strategies for preventing and treating malaria in vulnerable populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are young children under 11 years old living in malaria-endemic regions, particularly in Africa.
Not a fit: Patients who are not affected by malaria or are outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or vaccines that better protect children from severe malaria.
How similar studies have performed: Previous research has shown promising results in understanding antigenic variation in malaria, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEITSCH, KIRK W — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: DEITSCH, KIRK W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.