Understanding how malaria immunity works in vaccinated and unvaccinated children.
Official title: Harnessing the Malarial Immunity Omics Landscape in Vaccinated and Unvaccinated Children for Improved Therapeutic Strategies
Funded at University of New Mexico Health Scis Ctr · NIH-10999914 · Data updated 2026-11-12
This study is looking at how kids under 11 in high-risk areas of sub-Saharan Africa respond to malaria, by comparing blood samples from those who have been vaccinated and those who haven't, to learn more about how their bodies fight off the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $680,236 |
| NIH project number | 2R01AI130473-06A1 |
| Project ID | NIH-10999914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years living in areas with high malaria transmission, particularly those who have experienced malaria infections.
✕Less likely to help
Children who are not residing in malaria-endemic regions or those who are older than 11 years may not benefit from this research.
What this research studies
This research investigates the immune responses of children under 11 years old to malaria, particularly focusing on those in high-risk areas of sub-Saharan Africa. By analyzing blood samples from both vaccinated and unvaccinated children, the study aims to identify molecular profiles that contribute to immunity against malaria. The research will utilize advanced bioinformatics techniques to understand the genetic factors influencing severe malaria outcomes. Participants will be closely monitored to gather data on their health and immune responses over time.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies and vaccines for malaria, ultimately reducing morbidity and mortality in children.
How similar studies have gone: Previous research has shown promising results in understanding malaria immunity, but this specific approach of combining vaccinated and unvaccinated cohorts is relatively novel.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Perkins, Douglas Jay — University of New Mexico Health Scis Ctr
- Study coordinator: Perkins, Douglas Jay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.