Understanding how macrophages help heal heart tissue after a heart attack
Macrophages in Myocardial Infarction
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11049440
This study is looking at how certain immune cells called macrophages help heal the heart after a heart attack, and it’s exploring how a special protein affects their actions, which could lead to new ways to improve recovery for heart attack patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11049440 on ClinicalTrials.gov |
What this research studies
This research investigates the role of macrophages, a type of immune cell, in the healing process following a heart attack (myocardial infarction). It focuses on how these cells change in response to their environment and how a specific protein, Colony-Stimulating Factor (CSF)-1, influences their behavior. By using advanced techniques like single-cell transcriptomics and targeted genetic approaches, the study aims to uncover the mechanisms by which macrophages contribute to heart repair. The findings could lead to new therapeutic strategies to enhance recovery after heart attacks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction and are 21 years or older.
Not a fit: Patients who have not had a heart attack or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart healing and reduce complications after a heart attack.
How similar studies have performed: Previous research has shown promising results in understanding macrophage roles in heart repair, suggesting that this approach could yield valuable insights.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANGOGIANNIS, NIKOLAOS G — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: FRANGOGIANNIS, NIKOLAOS G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.