Understanding how macromolecules change shape and stability
Discovering and Manipulating Macromolecular Conformational Ensembles
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10895358
This study is looking at how large molecules in our bodies change shape and how these changes can be affected by different substances or genetic changes, with the goal of finding better ways to create medicines that can help treat infections and other health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10895358 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic behavior of macromolecules, focusing on how their structural states fluctuate and how these changes can be influenced by ligands and mutations. By moving beyond traditional static models, the research aims to develop new experimental methods to observe and manipulate these conformational ensembles. Techniques such as ensemble modeling and multitemperature crystallography will be employed to refine our understanding of these macromolecules, which could lead to improved drug design and therapeutic strategies. Patients may benefit from advancements in treatments targeting antibiotic resistance and other conditions influenced by macromolecular interactions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals affected by antibiotic-resistant infections or other diseases influenced by macromolecular interactions.
Not a fit: Patients with conditions unrelated to macromolecular behavior or those not affected by antibiotic resistance may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective drug designs and therapies for conditions related to antibiotic resistance and other diseases.
How similar studies have performed: Previous research has shown promising results in using similar approaches to understand macromolecular dynamics and improve drug design.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRASER, JAMES SOLOMON — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FRASER, JAMES SOLOMON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.