Understanding how m6A methylation affects cancer
Official title: m6A-suite: an informatics pipeline and resource for elucidating roles of m6A epitranscriptome in cancer
Funded at University of Pittsburgh at Pittsburgh · NIH-11044175 · Data updated 2026-11-12
This study is looking at how a specific change in RNA, called m6A methylation, affects cancer growth, and it's for researchers who want to better understand cancer and improve tools for studying it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 11, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $393,468 |
| NIH project number | 5U01CA279618-03 |
| Project ID | NIH-11044175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with various types of cancer who may benefit from advancements in understanding cancer biology.
✕Less likely to help
Patients with non-cancerous conditions or those not affected by m6A-related pathways may not receive direct benefits from this research.
What this research studies
This research focuses on the role of m6A methylation in cancer biology, which is a modification of mRNA that can influence gene expression. The team will develop an informatics pipeline called m6A-Suite to analyze and catalog m6A methylation patterns in cancer cells. By collaborating with cancer biologists, they aim to uncover how changes in m6A regulation can impact cancer growth and progression. This project will also address the need for better tools to identify and predict m6A regulatory mechanisms from profiling data.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer mechanisms and potential therapeutic targets.
How similar studies have gone: Other research has shown promising results in understanding m6A methylation in cancer, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Huang, Yufei — University of Pittsburgh at Pittsburgh
- Study coordinator: Huang, Yufei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.