Understanding how M. tuberculosis protects itself from stress
The role of nanocompartments in M. tuberculosis pathogenesis
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-10689049
This study is looking at how the tuberculosis bacteria protect themselves from the body's immune system, focusing on special structures they have that help them survive, which could lead to new ways to fight the infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-10689049 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacterium Mycobacterium tuberculosis survives in the human body by studying its unique nanocompartment system. These nanocompartments are specialized protein structures that help the bacteria defend against oxidative stress, which is a harmful condition caused by the immune system. The researchers aim to understand how these compartments work, particularly focusing on a specific enzyme that helps the bacteria resist damage from oxidative agents. By examining the role of these nanocompartments, the study hopes to uncover new insights into the survival mechanisms of this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with Mycobacterium tuberculosis or those at high risk of tuberculosis infection.
Not a fit: Patients who do not have tuberculosis or are not at risk for infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating tuberculosis by targeting the bacteria's defense mechanisms.
How similar studies have performed: Other research has shown promising results in understanding bacterial defense mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STANLEY, SARAH A — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: STANLEY, SARAH A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.