Understanding how lysyl oxidase affects blood vessel health
Official title: Cell-specific contributions of lysyl oxidase to arterial integrity
Funded at Washington University · NIH-11056778 · Data updated 2026-11-12
This study is looking at how a special enzyme called lysyl oxidase helps keep blood vessels strong, especially in people with aortic aneurysms, to find out how these dangerous conditions develop and progress, which could lead to better treatments or ways to prevent them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $470,899 |
| NIH project number | 5R01HL172996-02 |
| Project ID | NIH-11056778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of aortic aneurysms or those diagnosed with thoracic or abdominal aortic aneurysms.
✕Less likely to help
Patients without a history of aortic aneurysms or related vascular conditions may not benefit from this research.
What this research studies
This research investigates the role of lysyl oxidase, a key enzyme, in maintaining the integrity of blood vessels, particularly in the context of aortic aneurysms. By examining how this enzyme interacts with different cell types in the blood vessel walls, the study aims to uncover the mechanisms that lead to aneurysm formation and progression. The research employs advanced genetic and molecular techniques to analyze the contributions of lysyl oxidase in both thoracic and abdominal aortic aneurysms. Patients may benefit from insights that could lead to new treatments or preventive strategies for these life-threatening conditions.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that prevent the progression of aortic aneurysms and reduce the risk of life-threatening complications.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and molecular factors involved in aortic aneurysms, indicating that this approach has potential for success.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Halabi, Carmen M. — Washington University
- Study coordinator: Halabi, Carmen M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.