Understanding how lysosomes work in health and disease
Dissecting new mechanisms of lysosome quality control in health and disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11041055
This study is looking at how certain parts of cells called lysosomes work differently in pancreatic cancer cells compared to normal cells, to find out how cancer cells survive and possibly discover new ways to treat cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11041055 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lysosomes, which are essential for recycling materials and signaling in cells, particularly in the context of diseases like cancer and aging. The team will compare lysosomes from pancreatic cancer cells to those from normal cells to identify unique features that may help cancer cells survive and thrive. By using advanced techniques like proteomics, they aim to uncover how certain proteins, known as Ferlin proteins, help cancer cells manage stress on their lysosomes. This could lead to new insights into how to target cancer more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma or other conditions related to lysosomal dysfunction.
Not a fit: Patients with conditions unrelated to lysosomal function or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with pancreatic cancer and other diseases linked to lysosomal dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding lysosomal function in cancer, indicating that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PERERA, RUSHIKA MIRIAM — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: PERERA, RUSHIKA MIRIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.