Understanding how lysosomes work in cell health and disease
Functional characterization of lysosome membrane and its protein quality control system
This study is looking at how tiny parts of our cells called lysosomes work, especially in diseases like Alzheimer's and Huntington's, to find out how they help keep our cells healthy and how we might fix them when they don't work right.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10841304 on NIH RePORTER |
What this research studies
This research investigates the role of lysosomes, which are essential for breaking down and recycling materials in cells, particularly in relation to neurodegenerative diseases like Alzheimer's and Huntington's. The team aims to uncover how lysosomal proteins are regulated and how they contribute to cellular processes such as nutrient sensing and cell growth. By using advanced techniques to study lysosomal transport proteins and their functions, the research seeks to identify key proteins involved in the quality control of lysosomes. This could lead to a better understanding of how lysosomes malfunction in diseases and potentially inform new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases such as Alzheimer's or Huntington's disease.
Not a fit: Patients with non-neurodegenerative conditions or those without any lysosomal dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for neurodegenerative diseases, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding lysosomal functions and their implications in neurodegenerative diseases, suggesting that this approach has potential for success.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Li, Ming — University of Michigan at Ann Arbor
- Study coordinator: Li, Ming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.