Understanding how lysosomes respond to stress in cells
Official title: Lysosomal membrane dynamics during stress
Funded at Ohio State University · NIH-11021613 · Data updated 2026-11-12
This study looks at how tiny parts of our cells called lysosomes can fix themselves when they're under stress, which is important for people with conditions like Parkinson's and Crohn's disease, as it might help us find new ways to treat these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $393,750 |
| NIH project number | 1R35GM157207-01 |
| Project ID | NIH-11021613 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurological disorders such as Parkinson's disease or immune-related conditions like Crohn's disease.
✕Less likely to help
Patients with conditions unrelated to lysosomal dysfunction may not receive any benefit from this research.
What this research studies
This research investigates the behavior of lysosomes, which are essential cellular organelles, during stressful conditions that can lead to their damage. The study focuses on how lysosomes can repair themselves and prevent cell death when their membranes are compromised. By using advanced techniques like proteomics and microscopy, the research aims to uncover new cellular processes that help maintain lysosomal function, particularly in the context of diseases like Parkinson's and Crohn's disease. Patients may benefit from insights into how lysosomal dysfunction contributes to their conditions and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with lysosomal dysfunction, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding lysosomal function and its implications in various diseases, indicating that this approach has potential for success.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Bonet-Ponce, Luis — Ohio State University
- Study coordinator: Bonet-Ponce, Luis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.