Understanding how lysosomes repair themselves through lipid changes
Official title: Lysosomal quality control through lipid remodeling
Funded at University of Pittsburgh at Pittsburgh · NIH-10918080 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called lysosomes help keep our cells healthy and fix themselves when they get damaged, especially as we age or face certain diseases, and it hopes to find new ways to help improve their function for better overall health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $397,500 |
| NIH project number | 5R35GM150506-02 |
| Project ID | NIH-10918080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related diseases or conditions linked to lysosomal dysfunction, such as cardiovascular diseases.
✕Less likely to help
Patients with conditions unrelated to lysosomal function or those who are not experiencing age-related cellular stress may not benefit from this research.
What this research studies
This research investigates the role of lysosomes in cell health and their ability to repair themselves when damaged. It focuses on how lysosomal dysfunction is linked to aging and various diseases, including cardiovascular issues and neurodegeneration. By exploring a newly discovered pathway that helps lysosomes recover from damage, the research aims to identify potential therapeutic targets that could enhance cellular repair mechanisms. Patients may benefit from insights into how to improve lysosomal function and overall cellular health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with lysosomal dysfunction, improving patient outcomes.
How similar studies have gone: Other research has shown promise in understanding lysosomal function and repair mechanisms, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Tan, Xiaojun — University of Pittsburgh at Pittsburgh
- Study coordinator: Tan, Xiaojun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.