Understanding how lysosomes function in neurons affected by Alzheimer's disease
Moving and shaping neuronal lysosomes in Alzheimer's Disease
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11072693
This study is looking at how certain proteins in brain cells help control tiny structures called lysosomes, which are important for understanding Alzheimer's disease, and it hopes to find new ways to improve their function to help people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11072693 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control the functions of lysosomes and late endosomes in neurons, which are crucial for understanding Alzheimer's disease. The study focuses on specific proteins, JIP3 and JIP4, that play a role in regulating lysosome activity and their interactions with other cellular components. By exploring how these proteins operate differently in neurons, the research aims to uncover insights into the accumulation of lysosomes near amyloid plaques, a hallmark of Alzheimer's. This could lead to new strategies for modulating lysosome function for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with non-neurodegenerative conditions or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating Alzheimer's disease by improving lysosome function in neurons.
How similar studies have performed: While the specific approach of targeting lysosome function in neurons is novel, related research has shown promise in understanding neurodegenerative diseases through similar mechanisms.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERGUSON, SHAWN — YALE UNIVERSITY
- Study coordinator: FERGUSON, SHAWN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease