Understanding how lysosomes contribute to lung disease in women
Role of the Lysosome in the Pathogenesis and Therapy of LAM
This study is looking at how a specific gene mutation affects lung health in women with lymphangioleiomyomatosis (LAM) by exploring the role of tiny cell structures called lysosomes, with the hope of finding new ways to help improve treatment for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10633178 on NIH RePORTER |
What this research studies
This research investigates lymphangioleiomyomatosis (LAM), a serious lung disease that primarily affects women. It focuses on the role of lysosomes, which are cellular organelles involved in degradation and signaling, in the progression of LAM. The study aims to uncover how mutations in the TSC2 gene lead to increased lysosomal activity and contribute to lung damage. By examining the mechanisms behind these processes, the research seeks to identify potential therapeutic targets for improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with lymphangioleiomyomatosis (LAM), particularly those with TSC2 gene mutations.
Not a fit: Patients with lung diseases unrelated to LAM or those without the specific genetic mutations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or halt the progression of LAM, improving the quality of life for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of lysosomes in other diseases, suggesting that this approach may yield valuable insights for LAM as well.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Henske, Elizabeth P — Brigham and Women's Hospital
- Study coordinator: Henske, Elizabeth P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.