Understanding how lysosome damage contributes to liver disease from alcohol use
Role of Lysosome Damage in ALD Pathogenesis
['FUNDING_R21'] · AUBURN UNIVERSITY AT AUBURN · NIH-10990752
This study is looking at how drinking alcohol affects liver cells, especially how it damages tiny structures called lysosomes, which can lead to liver problems; the goal is to find new ways to treat or prevent alcohol-related liver disease.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUBURN UNIVERSITY AT AUBURN (nih funded) |
| Locations | 1 site (Auburn, UNITED STATES) |
| Trial ID | NIH-10990752 on ClinicalTrials.gov |
What this research studies
This research investigates the cellular and molecular changes that occur in the liver due to alcohol consumption, particularly focusing on how damage to lysosomes affects liver health. The study aims to identify specific alterations caused by alcohol metabolites that lead to lysosome damage in liver cells, which can result in cell death and inflammation. By understanding these mechanisms, the research seeks to uncover potential new treatment targets for alcohol-associated liver disease (ALD). The findings could help improve disease prognosis and develop therapies to prevent or alleviate ALD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of heavy alcohol consumption who are experiencing liver-related health issues.
Not a fit: Patients who do not consume alcohol or have liver disease due to non-alcoholic causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from alcohol-associated liver disease.
How similar studies have performed: While there has been some research on liver damage due to alcohol, the specific focus on lysosome damage in this context is relatively novel and untested.
Where this research is happening
Auburn, UNITED STATES
- AUBURN UNIVERSITY AT AUBURN — Auburn, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOMES, PAUL GIDEON — AUBURN UNIVERSITY AT AUBURN
- Study coordinator: THOMES, PAUL GIDEON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.