Understanding how lysosomal signaling contributes to kidney cancer development
Dissecting and targeting lysosomal signaling in kidney tumorigenesis
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11041147
This study is looking at how a specific protein called TFEB affects kidney cancer, especially in people with certain genetic conditions, to find new ways to treat the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11041147 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lysosomal signaling in kidney tumor formation, focusing on the Transcription Factor EB (TFEB), which regulates lysosomal function and autophagy. By using advanced mouse models and cell cultures, the study aims to uncover the mechanisms through which TFEB influences kidney cancer, particularly in conditions like Birt-Hogg-Dube syndrome and MiT-TFE renal cell carcinoma. The research employs various assays to analyze metabolic and signaling pathways involved in tumorigenesis, potentially leading to new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with kidney tumors, particularly those diagnosed with Birt-Hogg-Dube syndrome or MiT-TFE renal cell carcinoma.
Not a fit: Patients with kidney tumors not associated with lysosomal signaling or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating kidney cancers linked to lysosomal signaling.
How similar studies have performed: Other research has shown promising results in targeting lysosomal pathways in cancer, suggesting that this approach may be effective.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZONCU, ROBERTO — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: ZONCU, ROBERTO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.