Understanding how lysosomal proteins maintain pH balance in cells
Mechanisms of lysosomal ion transport proteins involved in pH homeostasis
This study is looking at how certain proteins help keep the tiny recycling centers in our cells, called lysosomes, working properly, which is important for brain health, especially for people with Parkinson's disease, and it hopes to find new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10986076 on NIH RePORTER |
What this research studies
This research investigates the role of specific lysosomal ion transport proteins, TMEM175 and CLC-7, in maintaining the acidic environment necessary for lysosomal function. By studying how mutations in these proteins affect lysosomal pH and cellular health, the research aims to uncover mechanisms that contribute to neurodegenerative diseases like Parkinson's. Patients may benefit from insights gained about how lysosomal dysfunction leads to the accumulation of toxic proteins in neurons, potentially guiding future therapies. The approach includes biochemical assays and cellular models to analyze the impact of these proteins on lysosomal homeostasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases, particularly those with a family history of conditions like Parkinson's Disease.
Not a fit: Patients with non-neurodegenerative conditions or those without genetic predispositions to lysosomal dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases by targeting lysosomal dysfunction.
How similar studies have performed: Previous research has shown that targeting lysosomal function can lead to significant advancements in understanding and treating neurodegenerative diseases, indicating a promising avenue for this investigation.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Hite, Richard Kevin — Sloan-Kettering Inst Can Research
- Study coordinator: Hite, Richard Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.