Understanding how lysosomal damage affects heart injury in diabetes
Official title: Deciphering the role of lysosomal membrane permeabilization in Diabetic Cardiac Injury
Funded at New York Inst of Technology · NIH-10359602 · Data updated 2026-11-12
This study is looking at how diabetes can harm the heart by focusing on tiny parts of our cells called lysosomes, and it aims to find ways to protect the heart from damage for people living with diabetes.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Inst of Technology NIH-funded |
| Lab location | 1 site (Old Westbury, United States) |
| Project start | February 15, 2022 |
| Project end | January 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $428,400 |
| NIH project number | 1R15HL161737-01 |
| Project ID | NIH-10359602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are at risk of developing heart disease.
✕Less likely to help
Patients without diabetes or those who do not have any heart-related complications may not benefit from this research.
What this research studies
This research investigates the mechanisms behind heart injury in diabetic patients, focusing on the role of lysosomes, which are cellular structures that help maintain cell health. The study aims to understand how lysosomal membrane permeabilization (LMP) leads to the leakage of harmful enzymes, contributing to heart damage. By examining diabetic mice and cultured heart cells, the researchers will explore how these processes can be targeted to protect the heart from injury. The ultimate goal is to develop strategies that could improve heart health in individuals with diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent heart damage in diabetic patients.
How similar studies have gone: Previous research has shown promising results in understanding lysosomal dysfunction in other diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
New York Inst of Technology
Old Westbury, United States Active
Researchers
- Principal investigator: Kobayashi, Satoru — New York Inst of Technology
- Study coordinator: Kobayashi, Satoru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.