Understanding how lysine methylation affects non-histone proteins and cellular processes
Regulation of non-histone protein function by lysine methylation
This study is looking at how a specific chemical change in proteins, called lysine methylation, affects important functions in our cells and how problems with this process might lead to diseases, with the hope that understanding this could help develop new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10914822 on NIH RePORTER |
What this research studies
This research investigates the role of lysine methylation in regulating non-histone proteins, which are crucial for various cellular functions. By utilizing advanced techniques like mass spectrometry, the team aims to identify how this modification influences biological processes and contributes to diseases. The study focuses on understanding the specificity of enzymes that add or remove lysine methylation and how their dysregulation can lead to health issues. Patients may benefit from insights gained about the mechanisms underlying their conditions, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions associated with enzyme dysregulation related to lysine methylation.
Not a fit: Patients with conditions unrelated to lysine methylation or non-histone protein function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to lysine methylation dysregulation.
How similar studies have performed: Previous research has shown promising results in understanding lysine methylation's role in histone proteins, suggesting potential for success in studying non-histone proteins.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Cornett, Evan Mitchell — Indiana University Indianapolis
- Study coordinator: Cornett, Evan Mitchell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.