Understanding how lymphatic vessels help heal wounds
Defining the role of lymphatic vessels in wound healing
This study is looking at how lymphatic vessels help heal skin wounds, especially in older mice, to see if boosting their repair can make healing better for older and diabetic folks, which could help with conditions like lymphedema that many people face.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11059953 on NIH RePORTER |
What this research studies
This research investigates the role of lymphatic vessels in the process of skin wound healing, particularly focusing on how their absence affects healing in aged mice. The study aims to uncover the cellular and molecular mechanisms that govern lymphatic vessel regeneration and their influence on blood vessel repair and fibrosis. By utilizing advanced genetic mouse models and cell culture techniques, the research will explore whether enhancing lymphatic vessel repair can improve wound healing in older and diabetic mice. This could lead to new insights into treating chronic conditions like lymphedema, which affects millions of Americans.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults and individuals with diabetes who experience chronic wounds or scarring.
Not a fit: Patients with acute wounds or those without issues related to lymphatic function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for wound healing and conditions like lymphedema, enhancing recovery and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of lymphatic vessels in healing, but this specific approach is novel and aims to fill existing knowledge gaps.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Horsley, Valerie — Yale University
- Study coordinator: Horsley, Valerie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.