Understanding how lymphatic vessels grow and function
Defining the Mechanisms of Lymphatic Vascular Growth and Function
This research explores how our body's lymphatic vessels, which help manage fluid and immunity, grow and are controlled.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10980566 on NIH RePORTER |
What this research studies
Lymphatic vessels are vital for maintaining fluid balance and supporting our immune system. This project focuses on lymphangiogenesis, the process by which these vessels grow from existing ones. We know that a signal called VEGF-C is crucial for this growth, and an imbalance can lead to problems. This work aims to uncover how other factors, such as fluid flow (laminar shear stress) and a protein called S1PR1, influence the VEGF-C signal. By using mouse models, we hope to understand the detailed interactions that keep lymphatic vessels healthy or contribute to disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but aims to benefit individuals with lymphatic disorders in the future.
Not a fit: Patients without conditions related to lymphatic vessel growth or function would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for conditions caused by problems with lymphatic vessel growth or function, such as lymphedema.
How similar studies have performed: This research builds upon well-established knowledge about lymphatic vessel growth, while exploring new regulatory mechanisms that are not yet fully understood.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Srinivasan, Rajanarayanan S — Oklahoma Medical Research Foundation
- Study coordinator: Srinivasan, Rajanarayanan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.