Understanding how lymphatic vessels develop and function
Regulation of Lymphatic Endothelial Cell Junction and Drainage
This study is looking at how inflammation impacts the growth and function of lymphatic vessels, which are important for keeping our body's fluids balanced and helping our immune system, and it aims to find ways to improve lymphatic health for people dealing with conditions like Alzheimer's disease and lymphedema.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11116794 on NIH RePORTER |
What this research studies
This research investigates the development and function of lymphatic vessels, which play a crucial role in maintaining fluid balance and immune response in the body. By using advanced three-dimensional models, the study aims to explore how inflammation affects the initial stages of lymphatic vessel formation and their ability to transport fluids. The research seeks to uncover the mechanisms behind lymphatic dysfunction, which can lead to various diseases, including Alzheimer's disease and lymphedema. Patients may benefit from insights gained into improving lymphatic health and addressing related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to lymphatic dysfunction, such as lymphedema, Alzheimer's disease, or other inflammatory diseases.
Not a fit: Patients without any lymphatic system disorders or related inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with lymphatic dysfunction, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding lymphatic function through advanced modeling techniques, indicating potential for success in this area.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Lee, Esak — Cornell University
- Study coordinator: Lee, Esak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.