Understanding how lymphatic vessels develop and function
Regulation of Lymphatic Endothelial Cell Junction and Drainage
This study is looking at how inflammation impacts the growth and function of lymphatic vessels, which are important for keeping our body's fluids balanced and helping our immune system, to find new ways to treat conditions like Alzheimer's disease and lymphedema that can arise when these vessels don't work properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10886073 on NIH RePORTER |
What this research studies
This research investigates the development and function of lymphatic vessels, which play a crucial role in maintaining fluid balance and immune responses in the body. By using advanced three-dimensional models, the study aims to explore how inflammation affects the formation and function of these vessels. The goal is to better understand the mechanisms behind lymphatic dysfunction, which can lead to various diseases, including Alzheimer's disease and lymphedema. Patients may benefit from insights gained through this research that could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to lymphatic dysfunction, such as Alzheimer's disease or lymphedema.
Not a fit: Patients with conditions unrelated to lymphatic function or those who do not have any symptoms of lymphatic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to lymphatic dysfunction, such as Alzheimer's disease and lymphedema.
How similar studies have performed: Previous research has shown promise in understanding lymphatic function using three-dimensional models, indicating that this approach could yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Lee, Esak — Cornell University
- Study coordinator: Lee, Esak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.