Understanding how lymphatic vessels control immune responses in germinal centers
Official title: Lymphatic control of germinal centers
Funded at New York University School of Medicine · NIH-11245000 · Data updated 2026-11-12
This study is looking at how tiny vessels in our body, called lymphatic vessels, help our immune system work better, especially in areas where important immune cells called B cells learn to fight infections and diseases; it’s for anyone interested in understanding how our body’s defenses can be improved, especially in fighting infections and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 12, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $806,693 |
| NIH project number | 1R01AI194463-01 |
| Project ID | NIH-11245000 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect the immune system, such as autoimmune diseases or cancers.
✕Less likely to help
Patients with stable, non-immune related conditions may not receive direct benefits from this research.
What this research studies
This research investigates the role of lymphatic vessels in regulating immune responses, particularly focusing on germinal centers where B cells mature and produce antibodies. By examining how these vessels change in response to inflammation, the study aims to uncover mechanisms that optimize the immune system's ability to fight infections and potentially improve anti-tumor therapies. The researchers will utilize advanced imaging techniques and experimental models to explore the relationship between lymphatic growth and immune cell function.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses against infections and cancers.
How similar studies have gone: Previous research has shown promising results in understanding the role of lymphatics in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Lund, Amanda W. — New York University School of Medicine
- Study coordinator: Lund, Amanda W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.