Understanding how lymphatic dysfunction contributes to COPD
Official title: Lymphatic Dysfunction in the Pathogenesis of COPD
Funded at Weill Medical Coll of Cornell Univ · NIH-11011336 · Data updated 2026-11-12
This study is looking at how problems with the lymphatic system might make lung damage worse in people with COPD, which is often caused by smoking, and it hopes to find new ways to help treat this condition by understanding the early signs of inflammation in the lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $639,868 |
| NIH project number | 5R01HL162990-03 |
| Project ID | NIH-11011336 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with COPD, particularly those with a history of cigarette smoke exposure.
✕Less likely to help
Patients with COPD who do not have a history of cigarette smoke exposure or those with other underlying lung conditions may not benefit from this research.
What this research studies
This research investigates the role of lymphatic dysfunction in the development of Chronic Obstructive Pulmonary Disease (COPD), a serious lung condition primarily caused by cigarette smoke. The study aims to uncover the early inflammatory events that lead to lung damage and how impaired lymphatic drainage may exacerbate these issues. By examining human lung tissue, researchers will explore the connection between lymphatic vessel injury and the severity of COPD, potentially identifying new therapeutic targets. The approach includes analyzing lymphatic function and its impact on immune responses in the lungs.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that modify the progression of COPD and improve patient outcomes.
How similar studies have gone: Previous research has indicated that targeting lymphatic function may offer new insights into treating inflammatory diseases, suggesting potential success for this approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Reed, Hasina Outtz — Weill Medical Coll of Cornell Univ
- Study coordinator: Reed, Hasina Outtz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.