Understanding how lymphatic dysfunction contributes to COPD
Lymphatic Dysfunction in the Pathogenesis of COPD
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11011336
This study is looking at how problems with the lymphatic system might make lung damage worse in people with COPD, which is often caused by smoking, and it hopes to find new ways to help treat this condition by understanding the early signs of inflammation in the lungs.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11011336 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lymphatic dysfunction in the development of Chronic Obstructive Pulmonary Disease (COPD), a serious lung condition primarily caused by cigarette smoke. The study aims to uncover the early inflammatory events that lead to lung damage and how impaired lymphatic drainage may exacerbate these issues. By examining human lung tissue, researchers will explore the connection between lymphatic vessel injury and the severity of COPD, potentially identifying new therapeutic targets. The approach includes analyzing lymphatic function and its impact on immune responses in the lungs.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with COPD, particularly those with a history of cigarette smoke exposure.
Not a fit: Patients with COPD who do not have a history of cigarette smoke exposure or those with other underlying lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that modify the progression of COPD and improve patient outcomes.
How similar studies have performed: Previous research has indicated that targeting lymphatic function may offer new insights into treating inflammatory diseases, suggesting potential success for this approach.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REED, HASINA OUTTZ — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: REED, HASINA OUTTZ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cell injury