Understanding how lymphatic drainage issues relate to chronic high blood pressure and brain health
Official title: Lymphatic drainage dysfunction in chronic hypertension
Funded at Yale University · NIH-11137782 · Data updated 2026-11-12
This study is looking at how problems with the lymphatic system might be linked to high blood pressure and its effects on brain health, especially in older adults, to help find new ways to prevent memory issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 15, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $672,472 |
| NIH project number | 5R01HL176017-02 |
| Project ID | NIH-11137782 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing chronic hypertension and related cognitive issues.
✕Less likely to help
Patients without chronic hypertension or those who do not exhibit cognitive impairment may not benefit from this research.
What this research studies
This research investigates the connection between lymphatic drainage dysfunction and chronic hypertension, particularly its impact on cerebral small vessel disease (cSVD), a leading cause of cognitive impairment in older adults. By studying a specific rat model, researchers aim to uncover how the lymphatic system's impairment may contribute to the development of cSVD. The study employs advanced imaging techniques and computational analysis to explore the relationship between lymphatic and glymphatic systems in the brain. The findings could provide insights into new therapeutic strategies for managing hypertension-related cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from cognitive impairments related to chronic hypertension.
How similar studies have gone: While the specific approach of linking lymphatic dysfunction to cSVD in the context of hypertension is novel, related studies have shown success in understanding the role of the glymphatic system in brain health.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Benveniste, Helene D — Yale University
- Study coordinator: Benveniste, Helene D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.