Understanding how lymphatic cells in the lungs develop and function
Biology of Lymphangiogenesis in the Adult Lung
['FUNDING_R01'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-10876248
This study is looking at special cells in the lungs that help with immune responses and how they change when we get infections, which could help us learn more about lung health and diseases for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10876248 on ClinicalTrials.gov |
What this research studies
This research investigates the biology of lymphatic endothelial cells (LECs) in the adult lung, focusing on their origins, replacement, and roles in immune responses. By studying how these cells react to infections, the research aims to uncover the mechanisms behind lymphangiogenesis, which is the formation of new lymphatic vessels. The approach involves using mouse models to observe changes in LEC populations following viral infections, providing insights into their proliferation and functional diversity. This knowledge could help improve our understanding of lung health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may have conditions affecting lung health or immune function.
Not a fit: Patients with non-lung related conditions or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating lung diseases by enhancing our understanding of immune responses and fluid balance in the lungs.
How similar studies have performed: Previous research has shown promising results in understanding lymphatic biology, but this specific focus on adult lung LECs is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FINE, ALAN FINE — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: FINE, ALAN FINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.