Understanding how lymph nodes influence transplant acceptance and immune responses
HVEM pathway regulating FRC function and transplant tolerance
This study is looking at how certain cells in lymph nodes can help or hurt the body's acceptance of transplanted organs, and it aims to find ways to make these cells work better so that transplants are more likely to be successful for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10868758 on NIH RePORTER |
What this research studies
This research investigates the role of lymph nodes in managing immune responses during organ transplantation, particularly focusing on how specific cells within these nodes can either promote or inhibit rejection of transplanted organs. The study aims to understand the mechanisms by which fibroblastic reticular cells (FRCs) in lymph nodes can transform into pro-inflammatory cells that may lead to transplant rejection. By exploring the LIGHT/HVEM signaling pathway, the researchers hope to find ways to restore the normal function of FRCs, potentially improving transplant tolerance through targeted drug delivery. This could lead to new therapeutic strategies that enhance the body's ability to accept transplanted organs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing organ transplantation, particularly those at risk of transplant rejection.
Not a fit: Patients who are not candidates for organ transplantation or those with conditions unrelated to transplant acceptance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for transplant patients by enhancing organ acceptance and reducing the need for long-term immunosuppressive therapy.
How similar studies have performed: Previous research has shown promise in understanding immune responses in transplantation, but this specific approach focusing on FRCs and the LIGHT/HVEM pathway is relatively novel.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Abdi, Reza — Brigham and Women's Hospital
- Study coordinator: Abdi, Reza
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.