Understanding how lymph nodes influence immune responses in organ transplantation
Lymph nodes at the crossroads of allo immunity and regulation
This study is looking at how lymph nodes help the body accept transplanted organs, with the goal of finding new ways to improve transplant success and make sure your body doesn’t reject the new organ.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10868755 on NIH RePORTER |
What this research studies
This research investigates the role of lymph nodes in organ transplantation, focusing on how they contribute to immune responses and tolerance. By studying the unique structure and function of lymph nodes, the research aims to develop new strategies to modulate the immune system for better transplant outcomes. The approach involves manipulating the lymph node microenvironment to promote anti-inflammatory responses and prevent graft rejection. Patients may benefit from improved long-term success rates of organ transplants through enhanced immune regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing or considering organ transplantation who may be at risk for graft rejection.
Not a fit: Patients who are not candidates for organ transplantation or those with stable grafts may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that improve the success of organ transplants and reduce the risk of rejection.
How similar studies have performed: Previous research has shown promise in manipulating immune responses in transplantation, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Abdi, Reza — Brigham and Women's Hospital
- Study coordinator: Abdi, Reza
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.