Understanding how lymph node metastasis affects cancer progression
Project 1 Mouse Models Analysis
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-10931491
This study is looking at how cancer cells in lymph nodes interact with immune cells, which might help the cancer spread, and it's aimed at finding new ways to improve treatment for people with solid tumors.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10931491 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lymph node (LN) metastasis in the progression of solid tumors, particularly how tumor cells interact with immune cells in the lymph nodes. Using mouse models, the study aims to uncover the mechanisms by which these interactions lead to immune tolerance, allowing cancer to spread to other parts of the body. The researchers will analyze the cellular and molecular changes that occur during these processes, with a focus on how these findings may apply to human cancers. By understanding these interactions, the research hopes to identify potential therapeutic targets to improve cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors that have metastasized to lymph nodes.
Not a fit: Patients with early-stage cancers that have not yet spread to lymph nodes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer metastasis and improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding immune interactions in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ENGLEMAN, EDGAR G. — STANFORD UNIVERSITY
- Study coordinator: ENGLEMAN, EDGAR G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.