Understanding how lymph node metastasis affects cancer progression
Official title: Project 1 Mouse Models Analysis
Funded at Stanford University · NIH-10931491 · Data updated 2026-11-12
This study is looking at how cancer cells in lymph nodes interact with immune cells, which might help the cancer spread, and it's aimed at finding new ways to improve treatment for people with solid tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $503,335 |
| NIH project number | 5U54CA274511-02 |
| Project ID | NIH-10931491 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors that have metastasized to lymph nodes.
✕Less likely to help
Patients with early-stage cancers that have not yet spread to lymph nodes may not benefit from this research.
What this research studies
This research investigates the role of lymph node (LN) metastasis in the progression of solid tumors, particularly how tumor cells interact with immune cells in the lymph nodes. Using mouse models, the study aims to uncover the mechanisms by which these interactions lead to immune tolerance, allowing cancer to spread to other parts of the body. The researchers will analyze the cellular and molecular changes that occur during these processes, with a focus on how these findings may apply to human cancers. By understanding these interactions, the research hopes to identify potential therapeutic targets to improve cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer metastasis and improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding immune interactions in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Engleman, Edgar G. — Stanford University
- Study coordinator: Engleman, Edgar G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.