Understanding how Lyme disease bacteria survive in mice
Identifying Determinants of Borrelia burgdorferi and Peromyscus leucopus symbiosis
['FUNDING_FELLOWSHIP'] · TUFTS UNIVERSITY BOSTON · NIH-10909049
This study is looking at how the Lyme disease bacteria live in white-footed mice without making them sick, which could help us find new ways to stop Lyme disease from spreading to people.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10909049 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between Borrelia burgdorferi, the bacteria that causes Lyme disease, and its natural host, the Peromyscus leucopus mouse. The study aims to uncover why these mice can carry the bacteria without showing symptoms and how the bacteria thrive within them. By using experimental methods to track infection dynamics and inflammation in these mice, the research seeks to identify potential targets for disrupting the cycle of Lyme disease transmission. This could lead to new strategies for preventing Lyme disease in humans.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research are individuals living in areas where Lyme disease is prevalent, particularly those who may be at risk of exposure.
Not a fit: Patients who are already diagnosed with Lyme disease and are receiving treatment may not directly benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for preventing Lyme disease, reducing the number of people who become infected.
How similar studies have performed: Other research has shown success in understanding host-pathogen interactions, making this approach promising for future breakthroughs in Lyme disease prevention.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOURGEOIS, JEFFREY — TUFTS UNIVERSITY BOSTON
- Study coordinator: BOURGEOIS, JEFFREY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.