Understanding how Lyme disease bacteria spread in the body
The roles of Lyme spirochete adhesins in hematogenous dissemination
This study is looking at how the bacteria that cause Lyme disease stick to and move through the body after a tick bite, with the goal of finding new ways to prevent or treat the disease, especially for those who might develop long-lasting symptoms like arthritis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11009068 on NIH RePORTER |
What this research studies
This research investigates how the bacteria that cause Lyme disease, particularly B. burgdorferi, attach to and spread through the body after being transmitted by a tick bite. The team uses various methods, including genetic analysis and animal models, to identify specific proteins that help the bacteria adhere to cells and tissues. By studying these interactions in detail, the researchers aim to uncover the mechanisms behind the bacteria's ability to cause chronic infections, such as arthritis. This knowledge could lead to new strategies for preventing or treating Lyme disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lyme disease, particularly those experiencing chronic symptoms like arthritis.
Not a fit: Patients who have not been diagnosed with Lyme disease or those with acute infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Lyme disease and its associated chronic conditions.
How similar studies have performed: Previous research has shown success in understanding bacterial adhesion mechanisms, suggesting that this approach could yield valuable insights into Lyme disease.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Coburn, Jenifer L — Medical College of Wisconsin
- Study coordinator: Coburn, Jenifer L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.