Understanding how Lyme Disease bacteria cause infection
Regulatory Pathways in Borrelial Pathogenesis
This study is looking at how a specific protein in the Lyme Disease bacteria helps it survive and cause illness in people, with the hope of finding new ways to prevent and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-10884367 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Borrelia burgdorferi, the bacteria responsible for Lyme Disease, establishes and maintains infection in humans. The study focuses on a key protein called BosR, which regulates the expression of genes necessary for the bacteria's survival and virulence during its lifecycle. By examining how BosR interacts with other genetic elements, the research aims to uncover new insights into the pathogenicity of Lyme Disease. This could lead to the development of better prevention and treatment strategies for those affected by the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lyme Disease or those who have been exposed to ticks in endemic areas.
Not a fit: Patients who do not have Lyme Disease or are not at risk of exposure to Borrelia burgdorferi may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for Lyme Disease, potentially reducing the incidence and severity of the infection.
How similar studies have performed: Previous research has shown success in understanding bacterial pathogenesis through similar regulatory pathway investigations, indicating a promising approach.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Skare, Jon T — Texas A&m University Health Science Ctr
- Study coordinator: Skare, Jon T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.