Understanding how Lyme disease bacteria affect immune responses
Elucidating the Bacterial and Host Mechanisms Governing B. burgdorferi-Related Type I Interferon Responses
This study is looking at how the bacteria that cause Lyme disease interact with our immune system, especially how they affect inflammation, to help find better ways to treat and manage the disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-10489389 on NIH RePORTER |
What this research studies
This research investigates how the bacteria causing Lyme disease, B. burgdorferi, interact with the immune system, particularly focusing on the type I interferon responses. By studying different strains of the bacteria and their genetic components, the researchers aim to uncover how these factors influence the body's inflammatory response and the progression of Lyme disease. The study employs advanced techniques, including genetic manipulation in human and mouse cells, to explore the mechanisms behind immune responses during infection. This could lead to a better understanding of how to manage and treat Lyme disease effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lyme disease or those experiencing symptoms related to Lyme disease.
Not a fit: Patients who do not have Lyme disease or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Lyme disease and its associated complications.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to bacterial infections, suggesting that this approach could yield valuable insights.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Hyde, Jenny a. — Texas A&m University Health Science Ctr
- Study coordinator: Hyde, Jenny a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.