Understanding how Lyme disease bacteria adapt to ticks and mammals
Elucidating the contributions of c-di-GMP and PlzA to tick- and mammalian host-adaptation in Lyme disease spirochetes
This study is looking at how the bacteria that cause Lyme disease change and move around in ticks and animals, which could help us understand more about the disease and how to prevent it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10850802 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the Lyme disease-causing bacteria, Borrelia burgdorferi, adapt to their tick and mammalian hosts. The study focuses on two key regulatory systems that control gene expression and motility in these bacteria, particularly how a signaling molecule called c-di-GMP influences their behavior. By examining the roles of specific proteins involved in this signaling, the research aims to uncover critical insights into the lifecycle of the bacteria and their transmission between hosts. This could lead to a better understanding of Lyme disease and its prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lyme disease or those at high risk of exposure to ticks.
Not a fit: Patients who do not have Lyme disease or are not at risk of tick exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating Lyme disease.
How similar studies have performed: Previous research has shown promising results in understanding bacterial adaptations in other infectious diseases, suggesting potential for success in this area as well.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Caimano, Melissa J — University of Connecticut Sch of Med/dnt
- Study coordinator: Caimano, Melissa J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.