Understanding how lupus develops and changes over time
Evolution of autoreactive GC and epitope spreading in lupus
This work explores how the immune system mistakenly attacks the body in lupus, focusing on how new targets for attack emerge.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11113883 on NIH RePORTER |
What this research studies
Systemic lupus erythematosus (SLE) is a challenging autoimmune disease where the body's immune system turns against itself. We know that over time, patients with lupus often develop new autoantibodies, which are immune proteins that attack the body's own tissues, a process called epitope spreading. This project aims to uncover the exact steps by which these new autoantibodies appear and contribute to the disease getting worse. By understanding these mechanisms, we hope to find new ways to stop or even prevent this harmful process in lupus.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals living with systemic lupus erythematosus.
Not a fit: Patients without systemic lupus erythematosus would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent the progression of lupus by stopping the immune system from attacking more parts of the body.
How similar studies have performed: While the phenomenon of epitope spreading in lupus is recognized, the precise mechanisms are still being uncovered, making this a novel approach to understanding its evolution.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Carroll, Michael Craig — Boston Children's Hospital
- Study coordinator: Carroll, Michael Craig
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.