Understanding how lung volume affects airway and chest wall changes in COPD
Official title: CT-based Characterization of Lung Volume-determined Airway and Chest Wall Deformation Interdependences in COPD
Funded at University of Iowa · NIH-10985337 · Data updated 2026-11-12
This study is looking at how the airways and chest wall change in people with COPD at different lung capacities, to better understand the different types of COPD and how they relate to other health issues like emphysema and low bone density, which could help improve treatment and outcomes for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $116,625 |
| NIH project number | 1R21HL175750-01 |
| Project ID | NIH-10985337 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease (COPD), particularly those with comorbidities such as emphysema or low bone density.
✕Less likely to help
Patients without a diagnosis of COPD or those with unrelated respiratory conditions may not benefit from this research.
What this research studies
This research investigates the mechanical changes in the airway and chest wall in patients with chronic obstructive pulmonary disease (COPD), particularly focusing on how these changes vary between different lung volumes. By utilizing CT scans and established datasets from nationwide lung studies, the research aims to identify unique subtypes of COPD-related abnormalities and their interactions with comorbidities like emphysema and low bone density. The study will analyze how these factors influence disease progression and clinical outcomes, providing insights into the pathophysiology of COPD.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of COPD, potentially enhancing treatment strategies and patient outcomes.
How similar studies have gone: Previous research has successfully utilized CT imaging to study lung mechanics in COPD, indicating that this approach is both established and promising.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Saha, Punam K. — University of Iowa
- Study coordinator: Saha, Punam K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.