Understanding how lung volume affects airway and chest wall changes in COPD
CT-based Characterization of Lung Volume-determined Airway and Chest Wall Deformation Interdependences in COPD
['FUNDING_R21'] · UNIVERSITY OF IOWA · NIH-10985337
This study is looking at how the airways and chest wall change in people with COPD at different lung capacities, to better understand the different types of COPD and how they relate to other health issues like emphysema and low bone density, which could help improve treatment and outcomes for patients.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10985337 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanical changes in the airway and chest wall in patients with chronic obstructive pulmonary disease (COPD), particularly focusing on how these changes vary between different lung volumes. By utilizing CT scans and established datasets from nationwide lung studies, the research aims to identify unique subtypes of COPD-related abnormalities and their interactions with comorbidities like emphysema and low bone density. The study will analyze how these factors influence disease progression and clinical outcomes, providing insights into the pathophysiology of COPD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease (COPD), particularly those with comorbidities such as emphysema or low bone density.
Not a fit: Patients without a diagnosis of COPD or those with unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of COPD, potentially enhancing treatment strategies and patient outcomes.
How similar studies have performed: Previous research has successfully utilized CT imaging to study lung mechanics in COPD, indicating that this approach is both established and promising.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAHA, PUNAM K. — UNIVERSITY OF IOWA
- Study coordinator: SAHA, PUNAM K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.