Understanding how lung transplant recipients respond to vaccinations
Vaccination responses in lung transplant recipients
This study is looking at how well lung transplant patients respond to COVID-19 vaccines, since they might not make enough antibodies, and it hopes to find better ways to protect them through improved vaccination strategies.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10892175 on NIH RePORTER |
What this research studies
This research investigates the immune responses of lung transplant recipients to vaccinations, particularly focusing on the COVID-19 mRNA vaccines. It aims to understand why these patients, who are often immunocompromised, may not produce adequate antibody responses after vaccination. By creating a biorepository of vaccine-related biological samples, the study will analyze the immune responses in detail, which could lead to improved vaccination strategies for this vulnerable population. The collaboration involves multiple institutions, including Stanford, to enhance the research's scope and impact.
Who could benefit from this research
Good fit: Ideal candidates for this research are lung transplant recipients who are immunocompromised and may have received COVID-19 vaccinations.
Not a fit: Patients who have not undergone lung transplantation or those who are not immunocompromised may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccination strategies for lung transplant recipients, improving their protection against infections.
How similar studies have performed: Previous studies have indicated challenges in vaccine responses among transplant recipients, suggesting that this research is addressing a critical and underexplored area.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Nicolls, Mark Robert — Stanford University
- Study coordinator: Nicolls, Mark Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.