Understanding how lung signals affect immune cell function during infections
Linking steady-state cytokine signaling to alveolar macrophage function in homeostasis and lung infection
This study looks at how certain immune cells in the lungs react to their surroundings during both good health and when fighting infections, like bacterial pneumonia, to find new ways to help improve our body's defense against these illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11129956 on NIH RePORTER |
What this research studies
This research investigates how alveolar macrophages, a type of immune cell in the lungs, respond to signals in their environment during both healthy states and infections. The study focuses on the role of specific proteins and signaling pathways that influence these immune cells' ability to switch between anti-inflammatory and pro-inflammatory responses. By examining how these processes are regulated, the research aims to uncover potential therapeutic targets for improving immune responses in lung infections, particularly bacterial pneumonia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic lung diseases or those at risk of bacterial pneumonia.
Not a fit: Patients with non-respiratory conditions or those without any lung-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response in patients with lung infections, potentially reducing mortality rates.
How similar studies have performed: Previous research has shown promising results in understanding immune cell functions in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Gottschalk, Rachel a — University of Pittsburgh at Pittsburgh
- Study coordinator: Gottschalk, Rachel a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.