Understanding how lung microbiome changes affect lung transplant rejection
Microbial Dysbiosis in Chronic Lung Allograft Dysfunction
This study is looking at how changes in the germs in the lungs might affect lung transplant patients who develop chronic lung problems, with the hope of finding ways to help improve their health and transplant success.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10896019 on NIH RePORTER |
What this research studies
This research investigates the relationship between changes in the lung microbiome and chronic lung allograft dysfunction (CLAD) in lung transplant recipients. By examining lung samples over time, the study aims to identify specific microbial patterns that may contribute to the development of CLAD. The researchers will also explore how these microbial changes affect the body's immune response and fibrosis, which can lead to transplant rejection. This work could provide insights into potential therapeutic strategies to improve lung transplant outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone a lung transplant and are at risk for chronic lung allograft dysfunction.
Not a fit: Patients who have not received a lung transplant or those without any signs of lung dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for lung transplant recipients, potentially enhancing their long-term survival.
How similar studies have performed: Previous research has shown that gut microbiome dysbiosis is linked to chronic inflammatory diseases, suggesting that similar approaches in lung microbiome studies may yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sharma, Nirmal S — Brigham and Women's Hospital
- Study coordinator: Sharma, Nirmal S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.