Understanding how lung macrophages respond to inflammation and infections
Official title: Role of resident macrophages in type II responses and trained immunity
Funded at New York University School of Medicine · NIH-11072329 · Data updated 2026-11-12
This study is looking at special immune cells in the lungs called macrophages to see how they help control inflammation and fight infections, which could lead to better treatments for breathing problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $831,755 |
| NIH project number | 1R01AI188824-01 |
| Project ID | NIH-11072329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from asthma or other chronic inflammatory lung diseases.
✕Less likely to help
Patients with non-inflammatory respiratory conditions or those without lung-related issues may not benefit from this research.
What this research studies
This research investigates the role of resident macrophages in the lungs, focusing on their functions in managing inflammation and responding to infections. It aims to uncover how these immune cells, particularly a specific subset known as CD169+ interstitial macrophages, operate within the unique environment of the lung. By studying these macrophages, the research seeks to understand their contributions to type 2 inflammatory responses and tissue repair after infections, which could lead to new therapeutic strategies for respiratory conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for asthma and other inflammatory lung diseases by targeting macrophage functions.
How similar studies have gone: Previous research has shown promising results in understanding macrophage roles in other tissues, suggesting potential for success in this novel approach.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Khanna, Kamal Mohan — New York University School of Medicine
- Study coordinator: Khanna, Kamal Mohan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.