Understanding how lung injury affects brain function during critical illness
Lung-Brain Axis as a Mediator of Delirium
This study is looking at how lung injuries, like Acute Respiratory Distress Syndrome (ARDS), might lead to confusion or delirium in patients by exploring changes in blood vessels and brain activity, with the hope of finding new ways to help those affected.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10851805 on NIH RePORTER |
What this research studies
This research investigates the connection between lung injury, specifically Acute Respiratory Distress Syndrome (ARDS), and the development of delirium in patients. It focuses on how the degradation of a protective layer in blood vessels, known as the endothelial glycocalyx, leads to changes in the brain that may cause cognitive disturbances. By examining the relationship between elevated levels of certain substances in the bloodstream and brain activity, the study aims to uncover the mechanisms behind delirium in ARDS patients. This could involve analyzing blood samples and brain function to identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Acute Respiratory Distress Syndrome, particularly those who may be experiencing or at risk for delirium.
Not a fit: Patients who do not have ARDS or those with pre-existing cognitive impairments unrelated to lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for delirium in patients suffering from ARDS, potentially reducing long-term disability and mortality.
How similar studies have performed: While the specific mechanisms being studied are novel, there is emerging evidence suggesting that understanding the lung-brain connection could lead to significant advancements in treating delirium in critically ill patients.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Hippensteel, Joseph Alan — University of Colorado Denver
- Study coordinator: Hippensteel, Joseph Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.