Understanding how lung injury affects blood vessel function
Mitochondrial mechanisms underlying alveolar-capillary barrier regulation
This study is looking at how lung injuries can lead to serious breathing problems in both kids and adults, and it aims to find new ways to help treat these conditions by understanding how damaged lung cells affect fluid in the lungs.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10866354 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind Acute Lung Injury (ALI) and its progression to Acute Respiratory Distress Syndrome (ARDS), which can be life-threatening for both children and adults. The study focuses on how signals from damaged alveoli affect the permeability of microvessels, leading to fluid buildup in the lungs. Using advanced microscopy techniques, the research observes real-time changes in lung tissue and mitochondrial function during injury. The goal is to uncover potential therapeutic targets to improve treatment options for ARDS.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from Acute Lung Injury or Acute Respiratory Distress Syndrome, particularly those who are critically ill.
Not a fit: Patients with chronic lung diseases unrelated to acute injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target the mechanisms of lung injury, improving outcomes for patients with ARDS.
How similar studies have performed: Previous research has shown promise in understanding the role of mitochondrial function in lung injury, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Hough, Rebecca Frances — Columbia University Health Sciences
- Study coordinator: Hough, Rebecca Frances
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.