Understanding how lung immune cells respond during influenza infections
Elucidating the roles of alveolar macrophage inflammation and self renewal during influenza infection
This study is looking at how certain immune cells in the lungs behave during infections like the flu and COVID-19, especially in older adults, to find ways to help improve lung health and recovery from these illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11130577 on NIH RePORTER |
What this research studies
This research investigates the role of alveolar macrophages, which are key immune cells in the lungs, during infections like influenza and COVID-19. It focuses on how these cells can become overly inflammatory, potentially leading to tissue damage, especially in older adults. The study aims to understand the balance between inflammation and self-renewal of these cells, and how age-related changes affect their function. By exploring these mechanisms, the research seeks to develop new treatments that could improve lung health and recovery from viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced severe respiratory infections or are at risk of complications from such infections.
Not a fit: Patients who are younger than 21 or those without a history of respiratory viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance lung recovery and reduce long-term health issues following respiratory viral infections.
How similar studies have performed: Previous research has shown promising results in understanding immune responses during viral infections, suggesting that this approach could yield valuable insights and therapeutic options.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Sun, Jie — University of Virginia
- Study coordinator: Sun, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.