Understanding how lung cells that produce platelets function and where they come from
Official title: The Origin and Function of Lung Megakaryocytes
Funded at University of Rochester · NIH-10996077 · Data updated 2026-11-12
This study is looking at special cells in the lungs that help make platelets and how they work with our immune system, so we can learn more about their role in keeping us healthy and possibly improve treatments for blood and immune-related conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 15, 2023 |
| Project end | September 14, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30HL165822-02 |
| Project ID | NIH-10996077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who may have conditions related to blood or immune system function.
✕Less likely to help
Patients with conditions unrelated to blood or immune system health may not receive any benefit from this research.
What this research studies
This research investigates the origin and immune functions of megakaryocytes, the cells responsible for producing platelets, specifically focusing on those found in the lungs. It aims to uncover how these lung megakaryocytes differ from those in the bone marrow and how they contribute to immune responses. By studying the mechanisms behind their immune differentiation, the research seeks to provide insights into their role in health and disease. Patients may benefit from a better understanding of how these cells function, which could lead to improved treatments for conditions related to blood and immune health.
Why it matters
Potential benefit: If successful, this research could lead to new insights into blood and immune disorders, potentially improving treatment options for patients.
How similar studies have gone: While the study of lung megakaryocytes is relatively novel, previous research has shown promising results in understanding immune functions of blood cells in other contexts.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Livada, Alison Claire — University of Rochester
- Study coordinator: Livada, Alison Claire
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.