Understanding how lung cells regenerate after injury
Official title: Control of lung alveolar regeneration by Dot1L/H3K79 methylation
Funded at University of Pennsylvania · NIH-11018540 · Data updated 2026-11-12
This study is looking at how certain lung cells can help heal damaged lungs, which could lead to better treatments for people with lung injuries or chronic lung diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $512,593 |
| NIH project number | 5R01HL162683-03 |
| Project ID | NIH-11018540 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute lung injuries or have chronic lung conditions affecting their alveoli.
✕Less likely to help
Patients with stable lung conditions that do not involve acute injury or significant regeneration needs may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the regeneration of lung alveoli, which are essential for breathing and responding to environmental threats. It focuses on a specific type of lung cell, the alveolar type 2 (AT2) cell, which can transform into another type of cell to help repair damaged lung tissue. By using advanced techniques, including small molecule screening and organoid assays, the study aims to identify pathways that enhance the repair process in the lungs. This could lead to new treatments for patients suffering from acute lung injuries or chronic lung diseases.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve lung healing and function in patients with acute lung injuries.
How similar studies have gone: Previous research has shown promise in understanding lung cell regeneration, but this specific approach focusing on Dot1L and H3K79 methylation is relatively novel.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Morrisey, Edward E — University of Pennsylvania
- Study coordinator: Morrisey, Edward E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.