Understanding how lung cells develop and recover after injury
Official title: Transcriptional and epigenetic mechanisms of alveologenesis and re-alveologenesis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11056703 · Data updated 2026-11-12
This study is looking at how lung cells heal and grow back after injuries, like those caused by COVID-19, to help us understand lung diseases better and find new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2031 |
| Funding year | 2025 |
| Award (this year) | $1,010,116 |
| NIH project number | 5R35HL171346-02 |
| Project ID | NIH-11056703 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants and children with chronic lung diseases or those recovering from acute lung injuries.
✕Less likely to help
Patients with stable lung conditions or those not affected by acute lung injuries may not receive direct benefits from this research.
What this research studies
This research investigates the complex processes of how lung cells, specifically those in the alveoli, develop and regenerate after injury, such as from diseases like COVID-19. By utilizing advanced single-cell technology, the study aims to uncover the transcriptional and epigenetic mechanisms that govern these processes. The research focuses on different cell types involved in lung function and aims to provide insights into conditions like bronchopulmonary dysplasia and acute lung injury. Patients may benefit from a better understanding of lung diseases and potential new treatments derived from this knowledge.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and outcomes for patients suffering from severe lung diseases.
How similar studies have gone: Previous research has shown promise in understanding lung cell development and regeneration, indicating that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Chen, Jichao — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Chen, Jichao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.