Understanding how lung cells can regenerate after severe injury
Official title: Mesenchymal cell plasticity and signaling in lung regeneration
Funded at University of Pennsylvania · NIH-10864439 · Data updated 2026-11-12
This study looks at how lung cells heal after serious injuries like those from COVID-19 or the flu, and it aims to find new ways to help patients recover better and faster.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $156,665 |
| NIH project number | 1K99HL173656-01 |
| Project ID | NIH-10864439 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have suffered severe lung injuries due to conditions like COVID-19 or influenza.
✕Less likely to help
Patients with mild lung injuries or those who have not experienced significant respiratory distress may not benefit from this research.
What this research studies
This research investigates how lung cells respond to severe injuries, such as those caused by COVID-19 or influenza. It focuses on the different types of cells involved in lung regeneration and how they communicate with each other in the damaged area. By studying these processes, the research aims to identify new therapies that can promote effective lung healing and restore normal function. Patients who have experienced severe lung injuries may find this research particularly relevant as it seeks to improve recovery outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung regeneration and improve long-term respiratory function for patients recovering from severe lung injuries.
How similar studies have gone: Other research has shown promise in understanding cell signaling and regeneration in various tissues, suggesting that this approach could yield valuable insights for lung healing.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Jones, Dakota L — University of Pennsylvania
- Study coordinator: Jones, Dakota L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.