Understanding how lung cells become activated in fibrosis
Fibrogenic activation and memory in the lung mesenchyme
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-11001577
This study is looking into how certain cells in the lungs, called fibroblasts, get turned on and stay active in conditions like pulmonary fibrosis, and it’s for anyone interested in understanding why lung problems can get worse over time.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11001577 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the activation of fibroblasts in the lungs, particularly in conditions like pulmonary fibrosis. It aims to understand how these cells can become persistently activated, leading to worsening lung conditions. By studying the role of a specific transcription factor called Runx1, the research will explore how fibroblasts remember their activated state and respond to repeated lung injuries. The approach includes using mouse models to track changes in fibroblast behavior during the progression of lung fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with interstitial lung diseases, particularly those with pulmonary fibrosis.
Not a fit: Patients with acute lung injuries or those without a diagnosis of interstitial lung disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that fundamentally alter the course of fibrotic lung diseases, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding fibroblast activation in other contexts, suggesting potential for success in this area.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TSCHUMPERLIN, DANIEL J. — MAYO CLINIC ROCHESTER
- Study coordinator: TSCHUMPERLIN, DANIEL J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.