Understanding how lung cancer cells change and adapt
Investigating the cell intrinsic and extrinsic mechanisms governing lung cancer cell plasticity
This study is looking at how lung cancer cells can change and become tougher to treat, using special technology to track these changes in mice, which could help us find better ways to treat lung cancer for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10865270 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that allow lung cancer cells to change their characteristics, which can lead to more aggressive behavior and resistance to treatments. By using advanced CRISPR technology, the study aims to track the lineage and state of cancer cells in a mouse model of lung adenocarcinoma. This approach will help identify key genetic networks involved in cancer cell plasticity, potentially leading to new treatment strategies. Patients may benefit from insights gained into how lung cancer evolves and how to better target therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lung cancer, particularly those with adenocarcinoma.
Not a fit: Patients with other types of cancer or those without a lung cancer diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for lung cancer by targeting the mechanisms that allow cancer cells to adapt and resist therapies.
How similar studies have performed: Other research has shown promise in using CRISPR technology to study cancer cell behavior, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Yang, Dian — Columbia University Health Sciences
- Study coordinator: Yang, Dian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.