Understanding how lung cancer cells change and adapt
Official title: Investigating the cell intrinsic and extrinsic mechanisms governing lung cancer cell plasticity
Funded at Columbia University Health Sciences · NIH-10865270 · Data updated 2026-11-12
This study is looking at how lung cancer cells can change and become tougher to treat, using special technology to track these changes in mice, which could help us find better ways to treat lung cancer for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $194,292 |
| NIH project number | 1K22CA289207-01 |
| Project ID | NIH-10865270 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with lung cancer, particularly those with adenocarcinoma.
✕Less likely to help
Patients with other types of cancer or those without a lung cancer diagnosis may not benefit from this research.
What this research studies
This research investigates the mechanisms that allow lung cancer cells to change their characteristics, which can lead to more aggressive behavior and resistance to treatments. By using advanced CRISPR technology, the study aims to track the lineage and state of cancer cells in a mouse model of lung adenocarcinoma. This approach will help identify key genetic networks involved in cancer cell plasticity, potentially leading to new treatment strategies. Patients may benefit from insights gained into how lung cancer evolves and how to better target therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for lung cancer by targeting the mechanisms that allow cancer cells to adapt and resist therapies.
How similar studies have gone: Other research has shown promise in using CRISPR technology to study cancer cell behavior, indicating that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Yang, Dian — Columbia University Health Sciences
- Study coordinator: Yang, Dian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.